Low Dose Intravenous Ascorbic Acid for Erythropoietin- Hyporesponsive Anemia in Hemodialysis Patients with Iron Overload
نویسندگان
چکیده
Department of Nephrology, Chang Gung Memorial Hospital, Chiayi, Taiwan Chang-Gung Memorial hospital, Department of Nephrology at Linko* Received: March, 2002 Revised: April, 2002 Accepted: May, 2002 Reprint requests address: Chun-Liang Lin, MD, Department of Nephrology Chang Gung Memorial Hospital, Chiayi (613) 6 West, Chia-Pu Road, Pu-tzu City, Chiayi, Taiwan Tel: (05) 3621000 ext. 2762 Fax: (05) 3623055 E-mail: [email protected] INTRODUCTION
منابع مشابه
بررسی میزان تأثیر اسید آسکوربیک وریدی در اصلاح آنمی بیماران مبتلا به نارسایی کلیه تحت درمان همودیالیز
Introduction: Hemodialysis patients often develop resistance to recombinant human erythropoietin due to functional Iron Deficiency. In these patients iron therapy can be hazardous leading to hemosiderosis. Recent studies have suggested that intravenous ascorbic acid may be able to improve this hyporeponsiveness. The aim of this study was to evaluate the effect of intravenous ascorbic acid on fu...
متن کاملIntravenous ascorbic acid as an adjuvant therapy for recombinant erythropoietin in hemodialysis patients with hyperferritinemia.
BACKGROUND Inadequate iron mobilization and defective iron utilization may cause recombinant erythropoietin (rEPO) hyporesponsiveness in hemodialysis (HD) patients with iron overload. We have demonstrated that intravenous ascorbic acid (IVAA), but not intravenous iron medication, can effectively circumvent the functional iron-deficient erythropoiesis associated with iron overload in HD patients...
متن کاملThe effect of intravenous ascorbic acid in hemodialysis patients with normoferritinemic anemia
BACKGROUND Hemodialysis (HD) patients with functional iron deficiency often develop resistance to recombinant human erythropoietin (rhEPO). Recent studies have shown that intravenous ascorbic acid (IVAA) administration could override rhEPO resistance in HD patients. This study was undertaken to test the effects of IVAA in HD patients with normoferritinemic functional iron deficiency accompanied...
متن کاملComparative Study of Intravenous Iron Versus Intravenous Ascorbic Acid for Treatment of Functional Iron Deficiency in Patients Under Hemodialysis: A Randomized Clinical Trial
BACKGROUND Functional iron deficiency (FID) may cause erythropoietin resistance in patients under hemodialysis (HD). Since the role of chronic inflammation or oxidative stress in its pathogenesis is unclear, controversy remains to whether intravenous iron or intravenous ascorbic acid (an antioxidant) can improve this anemia due to decreased iron availability. OBJECTIVES The current study comp...
متن کاملThe Frequency of Resistance to Synthetic Erythropoietin and Its Risk Factors among Chronic Hemodialysis Patients in Kerman
Background: The aim of this study was to determine the frequency of resistance to synthetic erythropoietin and factors affecting it among chronic hemodialysis patients in Kerman/ Iran. Methods: This cross- sectional study was performed on chronic hemodialysis patients of three hemodialysis centers in Kerman, Iran during 3 successive months in the summer of 201...
متن کامل